Pyrrolidinones derived from (S)-pyroglutamic acid:: penmacric acid and analogues -: Part V

被引：20

作者：

Anwar, M ^{[1
]}

Bailey, JH ^{[1
]}

Dickinson, LC ^{[1
]}

Edwards, HJ ^{[1
]}

Goswami, R ^{[1
]}

Moloney, MG ^{[1
]}

机构：

[1] Univ Oxford, Dyson Perrins Lab, Dept Chem, Oxford OX1 3QY, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 13期

关键词：

D O I：

10.1039/b303924b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylation reactions using alpha- halolactams or lactam enolates derived from bicyclic lactam templates can proceed with high endo- or exo- diastereoselectivity respectively. In the latter case, stereochemical correction by means of enolate generation and hindered phenol quench is possible with moderate efficiency. This protocol has been applied to the synthesis of protected penmacric acid and its analogues.

引用

页码：2364 / 2376

页数：13

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