The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae

被引:221
作者
Stapleton, Jack T. [1 ,2 ]
Foung, Steven [3 ]
Muerhoff, A. Scott [4 ]
Bukh, Jens [5 ,6 ,7 ,8 ]
Simmonds, Peter [8 ]
机构
[1] Vet Adm Med Ctr, Dept Internal Med, Iowa City, IA USA
[2] Univ Iowa, Iowa City, IA USA
[3] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA
[4] Abbott Labs, Abbott Diagnost Div, Abbott Pk, IL 60064 USA
[5] Copenhagen Univ Hosp, Copenhagen Hepatitis Program CO HEP C, Dept Infect Dis, Hvidovre, Denmark
[6] Copenhagen Univ Hosp, Clin Res Ctr, Hvidovre, Denmark
[7] Univ Copenhagen, Fac Hlth Sci, Dept Int Hlth Immunol & Microbiol, DK-1168 Copenhagen, Denmark
[8] Univ Edinburgh, Ctr Infect Dis, Edinburgh, Midlothian, Scotland
基金
美国国家卫生研究院;
关键词
HEPATITIS-G VIRUS; BLOOD MONONUCLEAR-CELLS; NON-B-HEPATITIS; TRANSFUSION-ASSOCIATED HEPATITIS; HUMAN-IMMUNODEFICIENCY-VIRUS; INTERNAL RIBOSOME ENTRY; IN-VITRO INFECTION; NEW-WORLD MONKEYS; VIRAL-HEPATITIS; STRAND RNA;
D O I
10.1099/vir.0.027490-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
In 1967, it was reported that experimental inoculation of serum from a surgeon (G.B.) with acute hepatitis into tamarins resulted in hepatitis. In 1995, two new members of the family Flaviviridae, named GBV-A and GBV-B, were identified in tamarins that developed hepatitis following inoculation with the 11th GB passage. Neither virus infects humans, and a number of GBV-A variants were identified in wild New World monkeys that were captured. Subsequently, a related human virus was identified [named GBV-C or hepatitis G virus (HGV)], and recently a more distantly related virus (named GBV-D) was discovered in bats. Only GBV-B, a second species within the genus Hepacivirus (type species hepatitis C virus), has been shown to cause hepatitis; it causes acute hepatitis in experimentally infected tamarins. The other GB viruses have however not been assigned to a genus within the family Flaviviridae. Based on phylogenetic relationships, genome organization and pathogenic features of the GB viruses, we propose to classify GBV-A-like viruses, GBV-C and GBV-D as members of a fourth genus in the family Flaviviridae, named Pegivirus (pe, persistent; g, GB or G). We also propose renaming 'GB' viruses within the tentative genus Pegivirus to reflect their host origin.
引用
收藏
页码:233 / 246
页数:14
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