Glycomimetics and glycodendrimers as high affinity microbial anti-adhesins

被引：214

作者：

Imberty, Anne ^{[1
]}

Chabre, Yoann M. ^{[2
]}

Roy, Rene ^{[2
]}

机构：

[1] Univ Grenoble 1, CERMAV CNRS, F-38041 Grenoble 9, France

[2] Univ Quebec, Dept Chim, Montreal, PQ H3C 3P8, Canada

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 25期

基金：

加拿大自然科学与工程研究理事会;

关键词：

adhesin; antiviral agents; dendrimers; glycomimetics; lectins;

D O I：

10.1002/chem.200800700

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Adhesion to epithelial surface is often the first step in bacterial and viral infection. In this process, the microbes use a variety of proteins for interaction with host carbohydrates presented as glycoconjugates on cell surfaces. Crystal structures of adhesin and lectin binding sites in complexes with oligosaccharide open the route for design and synthesis of glycomimetics, glycodendrimers, and glycopolymers that are able to block infection at an early stage.

引用

页码：7490 / 7499

页数：10

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