Cytokines in cancer pathogenesis and cancer therapy

被引：1137

作者：

Dranoff, G ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1252

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mixture of cytokines that is produced in the tumour microenvironment has an important role in cancer pathogenesis. Cytokines that are released in response to infection, inflammation and immunity can function to inhibit tumour development and progression. Alternatively, cancer cells can respond to host-derived cytokines that promote growth, attenuate apoptosis and facilitate invasion and metastasis. A more detailed understanding of cytokine-tumour-cell interactions provides new opportunities for improving cancer immunotherapy.

引用

页码：11 / 22

页数：12

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