MicroRNA Function in the Nervous System

被引：61

作者：

Fiore, Roberto ^{[1
,2
]}

Khudayberdiev, Sharof ^{[1
,2
]}

Saba, Reuben ^{[1
,2
]}

Schratt, Gerhard ^{[1
,2
]}

机构：

[1] Heidelberg Univ, Interdisziplinares Zentrum Neurowissensch, Jr Grp SFB488, Heidelberg, Germany

[2] Univ Klinikum Heidelberg, Inst Neuroanat, Heidelberg, Germany

来源：

PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE: CELLULAR RNA INTERFERENCE MECHANISMS, VOL 102 | 2011年 / 102卷

关键词：

MU-OPIOID RECEPTOR; MENTAL-RETARDATION PROTEIN; BRAIN-EXPRESSED MICRORNAS; NEURAL CELL SPECIFICATION; POSTTRANSCRIPTIONAL REGULATION; MESSENGER-RNA; SELF-RENEWAL; STEM-CELLS; OLIGODENDROCYTE DIFFERENTIATION; HUNTINGTONS-DISEASE;

D O I：

10.1016/B978-0-12-415795-8.00004-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are an extensive class of small noncoding RNAs that control posttranscriptional gene expression. miRNAs are highly expressed in neurons where they play key roles during neuronal differentiation, synaptogenesis, and plasticity. It is also becoming increasingly evident that miRNAs have a profound impact on higher cognitive functions and are involved in the etiology of several neurological diseases and disorders. In this chapter, we summarize our current knowledge of miRNA functions during neuronal development, physiology, and dysfunction.

引用

页码：47 / 100

页数：54

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