An efficient and simple aqueous N-heterocyclization of aniline derivatives:: Microwave-assisted synthesis of N-aryl azacycloalkanes

被引：108

作者：

Ju, YH ^{[1
]}

Varma, RS ^{[1
]}

机构：

[1] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 12期

关键词：

D O I：

10.1021/ol050683t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] An efficient and clean synthesis of N-aryl azacycloalkanes from alkyl dihalides and aniline derivatives has been achieved using microwave irradiation in an aqueous potassium carbonate medium. The phase separation can simplify the product isolation and reduce usage of volatile organic solvents.

引用

页码：2409 / 2411

页数：3

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