Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects

被引：30

作者：

Suh, YG

Lee, YS

Min, KH

Park, OH

Seung, HS

Kim, HD

Park, HG

Choi, JY

Lee, JW

Kang, SW

Oh, UT

Koo, JY

Joo, YH

Kim, SY

Kim, JK

Park, YH

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Sensory Res Ctr, CRI, Seoul 151742, South Korea

[3] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

[4] AmorePacific Corp, R&D Ctr, Yongin Si 449900, Gyounggi Do, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 24期

关键词：

D O I：

10.1016/j.bmcl.2003.09.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel non-vanilloid VR1 antagonist consisting of a new vanilloid equivalent exhibits excellent analgesic effects as well as highly potent antagonistic activities in both capsaicin single channel and calcium uptake assays. In addition, the structural requirement for the vanilloid equivalent of the potent VR1 antagonist has also been elucidated. (C) 2003 Elsevier Ltd. All rights reserved.

引用

收藏

页码：4389 / 4393

页数：5

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