Oligonucleotides with isopolar phosphonate internucleotide linkage:: A new perspective for antisense compounds?

被引：34

作者：

Rejman, D

Snásel, J

Liboska, R

Tocík, Z

Paces, O

Králíková, S

Rinnová, M

Kois, P

Rosenberg, I

机构：

[1] Acad Sci Czech Republic, Inst Organ Chem & Biochem, CR-16610 Prague 6, Czech Republic

[2] Comenius Univ, Dept Organ Chem, Bratislava, Slovakia

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 4-7期

关键词：

D O I：

10.1081/NCN-100002437

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.

引用

页码：819 / 823

页数：5

共 12 条

[1] 2′,3′-O-phosphonoalkylidene derivatives of ribonucleosides:: Synthesis and reactivity [J].