UV spectroscopy study on complexes of phosphonate ApA analogs with poly(U):: Promising step in prediction of oligonucleotide analog properties?

被引：25

作者：

Pressová, M ^{[1
]}

Endová, M ^{[1
]}

Tocík, Z ^{[1
]}

Liboska, R ^{[1
]}

Rosenberg, I ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-16610 Prague 6, Czech Republic

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(98)00190-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The isopolar nonisosteric phosphonate analogs of ApA differing in the position of extra methylene group introduced into the sugar-phosphate backbone, featuring both possible 2',5'- and 3',5'- pairs as well as their conformationally restricted congeners, were investigated for their ability to form complexes with polyU. The results may lead to the specification of candidates for synthesis of novel oligonucleotides. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1225 / 1230

页数：6

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