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The underlying molecular mechanism of apolipoprotein E polymorphism - Relationships to lipid disorders, cardiovascular disease, and Alzheimer's disease

被引：37
作者：
Contois, JH [1 ]
Anamani, DE [1 ]
Tsongalis, GJ [1 ]
机构：
[1] HARTFORD HOSP, DEPT PATHOL & LAB MED, HARTFORD, CT 06102 USA
来源：
CLINICS IN LABORATORY MEDICINE | 1996年 / 16卷 / 01期
关键词：
D O I：
10.1016/S0272-2712(18)30290-7
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Apolipoprotein E (apo E) polymorphism has important clinical correlates, including disorders of Lipoprotein metabolism and atherosclerosis. This article provides a detailed methodology for apo E genotyping and discusses the link between apo E genotype and type III hyperlipoproteinemia, coronary heart disease (CHD), stroke, and Alzheimer's disease (AD). Although apo E genotype appears to provide significant information concerning the genetic component of CHD and AD risk, more research is needed before genotyping can be recommended as a routine screening tool. The data so far, however, implicate apo E as a major component of the genetic basis of cardiovascular disease and AD.
引用
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页码：105 / +
页数：1
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