To evaluate the genetic control of stress responses in Arabidopsis, we have analyzed a mutant (uvh6-1) that exhibits increased sensitivity to UV light, a yellow-green leaf coloration, and mild growth defects. We have mapped the uvh6-1 locus to chromosome I and have identified a candidate gene, AtXPD, within the corresponding region. This gene shows sequence similarity to the human (Homo sapiens) XPD and yeast (Saccharomyces cerevisiae) RAD3 genes required for nucleotide excision repair. We propose that UVH6 is equivalent to AtXPD because uvh6-1 mutants carry a mutation in a conserved residue of AtXPD and because transformation of uvh6-1 mutants with wild-type AtXPD DNA suppresses both UV sensitivity and other defective phenotypes. Furthermore, the UVH6/AtXPD protein appears to play a role in repair of UV photoproducts because the uvh6-1 mutant exhibits a moderate defect in the excision of UV photoproducts. This defect is also suppressed by transformation with UVH6/AtXPD DNA. We have further identified a T-DNA insertion in the UVH6/AtXPD gene (uvh6-2). Plants carrying homozygous insertions were not detected in analyses of progeny from plants heterozygous for the insertion. Thus, homozygous insertions appear to be lethal. We conclude that the UVH6/AtXPD gene is required for UV resistance and is an essential gene in Arabidopsis.
机构:
UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957
BRITT, AB
;
CHEN, JJ
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UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957
CHEN, JJ
;
WYKOFF, D
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h-index: 0
机构:
UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957
WYKOFF, D
;
MITCHELL, D
论文数: 0引用数: 0
h-index: 0
机构:
UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Costa, RMA
;
Morgante, PG
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Morgante, PG
;
Berra, CM
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Berra, CM
;
Nakabashi, M
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Nakabashi, M
;
Bruneau, D
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Bruneau, D
;
Bouchez, D
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Bouchez, D
;
Sweder, KS
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Sweder, KS
;
Van Sluys, MA
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Van Sluys, MA
;
Menck, CFM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Costa, RMA
;
Lima, WC
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h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Lima, WC
;
Vogel, CIG
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h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Vogel, CIG
;
Berra, CM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Berra, CM
;
Luche, DD
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机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Luche, DD
;
Medina-Silva, R
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Medina-Silva, R
;
Galhardo, RS
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机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Galhardo, RS
;
Menck, CFM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Menck, CFM
;
Oliveira, VR
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h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
机构:
UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957
BRITT, AB
;
CHEN, JJ
论文数: 0引用数: 0
h-index: 0
机构:
UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957
CHEN, JJ
;
WYKOFF, D
论文数: 0引用数: 0
h-index: 0
机构:
UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957
WYKOFF, D
;
MITCHELL, D
论文数: 0引用数: 0
h-index: 0
机构:
UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957UNIV TEXAS,MD ANDERSON CANC RES CTR,DEPT CARCINOGENESIS,SMITHVILLE,TX 78957
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Costa, RMA
;
Morgante, PG
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Morgante, PG
;
Berra, CM
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Berra, CM
;
Nakabashi, M
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Nakabashi, M
;
Bruneau, D
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Bruneau, D
;
Bouchez, D
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Bouchez, D
;
Sweder, KS
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Sweder, KS
;
Van Sluys, MA
论文数: 0引用数: 0
h-index: 0
机构:Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Van Sluys, MA
;
Menck, CFM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Costa, RMA
;
Lima, WC
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Lima, WC
;
Vogel, CIG
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Vogel, CIG
;
Berra, CM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Berra, CM
;
Luche, DD
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Luche, DD
;
Medina-Silva, R
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Medina-Silva, R
;
Galhardo, RS
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h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Galhardo, RS
;
Menck, CFM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil
Menck, CFM
;
Oliveira, VR
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil