Characteristics and Treatment of Seizures in Patients with High-Grade Glioma: A Review

被引：37

作者：

Englot, Dario J. ^{[1
,2
]}

Berger, Mitchel S. ^{[2
,3
]}

Chang, Edward F. ^{[1
,2
]}

Garcia, Paul A. ^{[2
,4
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, UCSF Epilepsy Ctr, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, UCSF Brain Tumor Res Ctr, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

来源：

NEUROSURGERY CLINICS OF NORTH AMERICA | 2012年 / 23卷 / 02期

关键词：

Anaplastic astrocytoma; Epilepsy; High-grade glioma; Glioblastoma; Seizure; DIAGNOSED BRAIN-TUMORS; TEMPORAL-LOBE EPILEPSY; QUALITY-OF-LIFE; ANTIEPILEPTIC DRUGS; GLIOBLASTOMA-MULTIFORME; PHASE-II; PROPHYLACTIC ANTICONVULSANTS; POSTOPERATIVE EPILEPSY; INTRACTABLE EPILEPSY; GLUTAMINE-SYNTHETASE;

D O I：

10.1016/j.nec.2012.01.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

High-grade gliomas (HGGs), including anaplastic astrocytoma and glioblastoma multiforme, are the most common primary brain tumors, and are often associated with seizures. Seizure control is a critical but often underappreciated goal in the treatment of patients harboring these malignant lesions. Patients with HGG who also have medically intractable seizures should be considered for a palliative resection guided by electrocorticography and functional mapping. Antiepileptic drugs remain the mainstay of seizure treatment in HGG, and antiepileptic medication should be started after a tumor-related seizure, but should not be used prophylactically in the absence of seizure activity.

引用

页码：227 / +

页数：11

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