Lipid-induced β-cell dysfunction and oxidative stress

被引：2

作者：

Oprescu, Andrei I.

Giacca, Adria

机构：

[1] Univ Toronto, Inst Med Sci, Toronto, ON M4X 1K9, Canada

[2] Univ Toronto, Dept Physiol, Toronto, ON M4X 1K9, Canada

来源：

FUTURE LIPIDOLOGY | 2007年 / 2卷 / 04期

关键词：

beta-cells; islets; lipotoxicity; type; 2; diabetes;

D O I：

10.2217/17460875.2.4.455

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Type 2 diabetes is characterized by both insulin resistance and defective insulin secretion. Obesity is the major predisposing factor for Type 2 diabetes and is associated with excessive release of fatty acids from the expanded adipose tissue, leading to elevated plasma free fatty acid, known to induce insulin resistance and decrease p-cell function and mass. The purpose of this review is to discuss the mechanisms of the effect of prolonged fat exposure on pancreatic p-cells, known as lipotoxicity, with particular regard to p-cell function. The role of oxidative stress is emphasized, as it was shown by recent studies to play a significant role in the development of lipotoxicity and Type 2 diabetes.

引用

收藏

页码：455 / 463

页数：9

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