Bioactive ent-clerodane diterpenoids from Scutellaria barbata

被引：48

作者：

Dai, Sheng-Jun ^{[1
]}

Sun, Jing-Yong ^{[1
]}

Ren, Yan ^{[1
]}

Liu, Ke ^{[1
]}

Shen, Li ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharmaceut Sci, Yantai 264005, Peoples R China

来源：

PLANTA MEDICA | 2007年 / 73卷 / 11期

关键词：

D O I：

10.1055/s-2007-990215

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Four new ent-clerodane diterpenoids were isolated from the whole plant of Scutellaria barbata D. Don. (Labiatae). Their structures were elucidated by chemical methods and spectral analyses. In vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range 3.1 - 7.2 mu M.

引用

页码：1217 / 1220

页数：4

共 4 条

[1]

Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines [J].