Template-assembled synthetic G-quartets (TASQs)

被引：61

作者：

Nikan, Mehran ^{[1
]}

Sherman, John C. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 26期

关键词：

cavitands; G-quartets; nucleosides; supramolecular chemistry; template synthesis;

D O I：

10.1002/anie.200704199

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An unusual quartet: Four guanine residues have been efficiently "clicked" onto a cavitand to create a lipophilic template-assembled synthetic G-quartet (TASQ) structure in CDCl3. The TASQ manifests unusual cation-free structural integrity and stability. This cation-free basket, as well as corresponding potential cation-bound quartets and cation-induced quadruplexes may find applications in health therapies. (Figure Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4900 / 4902

页数：3

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