The Drosophila polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1

被引：294

作者：

Brown, JL ^{[1
]}

Mucci, D ^{[1
]}

Whiteley, M ^{[1
]}

Dirksen, ML ^{[1
]}

Kassis, JA ^{[1
]}

机构：

[1] US FDA, Dev Biol Lab, Div Cellular & Gene Therapies, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

来源：

MOLECULAR CELL | 1998年 / 1卷 / 07期

关键词：

D O I：

10.1016/S1097-2765(00)80106-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genes of the Polycomb group (PcG) of Drosophila encode proteins necessary for the maintenance of transcriptional repression of homeotic genes. PcG proteins are thought to act by binding as multiprotein complexes to DNA through Polycomb group response elements (PREs); however, specific DNA binding has not been demonstrated for any of the PcG proteins. We have identified a sequence-specific DNA binding protein that interacts with a PRE from the Drosophila engrailed gene. This protein (PHO) is a homolog of the ubiquitous mammalian transcription factor Yin Yang-1 and is encoded by pleiohomeotic, a known member of the PcG. We propose that PHO acts to anchor PcG protein complexes to DNA.

引用

页码：1057 / 1064

页数：8

共 72 条

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