Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone

被引：164

作者：

Tudor, JE

Pallaghy, PK

Pennington, MW

Norton, RS

机构：

[1] BIOMOL RES INST,NUCL MAGNET RESONANCE LAB,PARKVILLE,VIC 3052,AUSTRALIA

[2] BACHEM BIOSCI INC,KING OF PRUSSIA,PA 19406

来源：

NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 04期

关键词：

D O I：

10.1038/nsb0496-317

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first structure of a sea anemone potassium channel toxin reveals how a novel structural scaffold can be used to present key functional groups for channel blockade.

引用

页码：317 / 320

页数：4

共 29 条

[1] TOPOLOGY OF THE PORE-REGION OF A K+ CHANNEL REVEALED BY THE NMR-DERIVED STRUCTURES OF SCORPION TOXINS [J].

AIYAR, J ;

WITHKA, JM ;

RIZZI, JP ;

SINGLETON, DH ;

ANDREWS, GC ;

LIN, W ;

BOYD, J ;

HANSON, DC ;

SIMON, M ;

DETHLEFS, B ;

LEE, CL ;

HALL, JE ;

GUTMAN, GA ;

CHANDY, KG .

NEURON, 1995, 15 (05) :1169-1181

[2] A POTASSIUM CHANNEL TOXIN FROM THE SECRETION OF THE SEA-ANEMONE BUNODOSOMA-GRANULIFERA - ISOLATION, AMINO-ACID-SEQUENCE AND BIOLOGICAL-ACTIVITY [J].

ANEIROS, A ;

GARCIA, I ;

MARTINEZ, JR ;

HARVEY, AL ;

ANDERSON, AJ ;

MARSHALL, DL ;

ENGSTROM, A ;

HELLMAN, U ;

KARLSSON, E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1157 (01) :86-92

[3] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES [J].

BERNSTEIN, FC ;

KOETZLE, TF ;

WILLIAMS, GJB ;

MEYER, EF ;

BRICE, MD ;

RODGERS, JR ;

KENNARD, O ;

SHIMANOUCHI, T ;

TASUMI, M .

JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) :535-542

[4] ANALYSIS OF SIDE-CHAIN ORGANIZATION ON A REFINED MODEL OF CHARYBDOTOXIN - STRUCTURAL AND FUNCTIONAL IMPLICATIONS [J].

BONTEMS, F ;

GILQUIN, B ;

ROUMESTAND, C ;

MENEZ, A ;

TOMA, F .

BIOCHEMISTRY, 1992, 31 (34) :7756-7764

[5] CHARACTERIZATION OF A POTASSIUM CHANNEL TOXIN FROM THE CARIBBEAN SEA-ANEMONE STICHODACTYLA-HELIANTHUS [J].

CASTANEDA, O ;

SOTOLONGO, V ;

AMOR, AM ;

STOCKLIN, R ;

ANDERSON, AJ ;

HARVEY, AL ;

ENGSTROM, A ;

WERNSTEDT, C ;

KARLSSON, E .

TOXICON, 1995, 33 (05) :603-613

[6] STRUCTURE AND FUNCTION OF VOLTAGE-GATED ION CHANNELS [J].

CATTERALL, WA .

ANNUAL REVIEW OF BIOCHEMISTRY, 1995, 64 :493-531

[7] KALIOTOXIN(1-37) SHOWS STRUCTURAL DIFFERENCES WITH RELATED POTASSIUM CHANNEL BLOCKERS [J].

FERNANDEZ, I ;

ROMI, R ;

SZENDEFFY, S ;

MARTINEAUCLAIRE, MF ;

ROCHAT, H ;

VANRIETSCHOTEN, J ;

PONS, M ;

GIRALT, E .

BIOCHEMISTRY, 1994, 33 (47) :14256-14263

[8] THE CHARYBDOTOXIN RECEPTOR OF A SHAKER K+ CHANNEL - PEPTIDE AND CHANNEL RESIDUES MEDIATING MOLECULAR RECOGNITION [J].

GOLDSTEIN, SAN ;

PHEASANT, DJ ;

MILLER, C .

NEURON, 1994, 12 (06) :1377-1388

[9] NEUROPHARMACOLOGY OF POTASSIUM-ION CHANNELS [J].

HARVEY, AL .

MEDICINAL RESEARCH REVIEWS, 1993, 13 (01) :81-104

[10] REVEALING THE ARCHITECTURE OF A K+ CHANNEL PORE THROUGH MUTANT CYCLES WITH A PEPTIDE INHIBITOR [J].

HIDALGO, P ;

MACKINNON, R .

SCIENCE, 1995, 268 (5208) :307-310

← 1 2 3 →