Synthesis of 3-(4-tert-butylphenyl)-2-propen-1-one, a precursor to Lilial®, via an aldol condensation in an ionic liquid

被引：21

作者：

Davey, PN

Forsyth, SA

Gunaratne, HQN

Hardacre, C ^{[1
]}

McKeown, A

McMath, SEJ

Rooney, DW

Seddon, KR

机构：

[1] Quest Int, Ashford TN24 0LT, Kent, England

[2] Queens Univ Belfast, Sch Chem, Belfast BT9 5AG, Antrim, North Ireland

[3] Queens Univ Belfast, QUILL Res Ctr, Belfast BT9 5AG, Antrim, North Ireland

[4] Queens Univ Belfast, Sch Chem Engn, Belfast BT9 5AG, Antrim, North Ireland

来源：

GREEN CHEMISTRY | 2005年 / 7卷 / 04期

关键词：

D O I：

10.1039/b416021e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of a precursor to Lilial(R), based on an aldol condensation in an ionic liquid, is described, utilising piperidine as the base catalyst. The yields obtained with this methodology are significantly increased in comparison with those reported in organic solvents to date. In the ionic liquid, the self-aldol condensation of propanal is suppressed and leads to an increased selectivity with respect to the cross-aldol condensation product without the need to use an excess of 4-tert-butylbenzaldehyde to obtain high selectivities.

引用

页码：224 / 229

页数：6

共 48 条

[11]

Chauvin Y, 1995, ANGEW CHEM INT EDIT, V34, P2698

[12]

Chowdari NS, 2003, SYNLETT, P1906

[13] Increasing the basicity and catalytic activity of hydrotalcites by different synthesis procedures [J].