Real-time mass sensing by nanomechanical resonators in fluid

被引：13

作者：

Ghatkesar, MK ^{[1
]}

Barwich, V ^{[1
]}

Braun, T ^{[1
]}

Bredekamp, AH ^{[1
]}

Drechsler, U ^{[1
]}

Despont, M ^{[1
]}

Lang, HP ^{[1
]}

Hegner, M ^{[1
]}

Gerber, C ^{[1
]}

机构：

[1] Univ Basel, Inst Phys, CH-4003 Basel, Switzerland

来源：

PROCEEDINGS OF THE IEEE SENSORS 2004, VOLS 1-3 | 2004年

关键词：

cantilever sensor; bio-sensor; mass measurement;

D O I：

10.1109/ICSENS.2004.1426357

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We have developed a sensitive method for real-time mass sensing in a fluid using a microfabricated array of nanomechanical cantilevers actuated at their resonance frequencies. The sensor platform consists of a streptavidin layer immobilised onto gold-coated cantilevers and interacts with biotin-labeled latex beads. The addition of mass involved with this process decreased the resonance frequency. By monitoring frequency spectra of higher harmonies we measured a mass sensitivity of 3.3 Hz/pg. Our data demonstrate that the sensitivity can be increased by operating the cantilever at higher harmonics.

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收藏

页码：1060 / 1063

页数：4

相关论文

共 10 条

[1] SCAN SPEED LIMIT IN ATOMIC FORCE MICROSCOPY [J].

BUTT, HJ ;

SIEDLE, P ;

SEIFERT, K ;

FENDLER, K ;

SEEGER, T ;

BAMBERG, E ;

WEISENHORN, AL ;

GOLDIE, K ;

ENGEL, A .

JOURNAL OF MICROSCOPY-OXFORD, 1993, 169 :75-84

[2] RESONANCE RESPONSE OF SCANNING FORCE MICROSCOPY CANTILEVERS [J].

CHEN, GY ;

WARMACK, RJ ;

THUNDAT, T ;

ALLISON, DP ;

HUANG, A .

REVIEW OF SCIENTIFIC INSTRUMENTS, 1994, 65 (08) :2532-2537

[3] Translating biomolecular recognition into nanomechanics [J].

Fritz, J ;

Baller, MK ;

Lang, HP ;

Rothuizen, H ;

Vettiger, P ;

Meyer, E ;

Güntherodt, HJ ;

Gerber, C ;

Gimzewski, JK .

SCIENCE, 2000, 288 (5464) :316-318

[4] OBSERVATION OF A CHEMICAL-REACTION USING A MICROMECHANICAL SENSOR [J].

GIMZEWSKI, JK ;

GERBER, C ;

MEYER, E ;

SCHLITTLER, RR .

CHEMICAL PHYSICS LETTERS, 1994, 217 (5-6) :589-594

[5] Single virus particle mass detection using microresonators with nanoscale thickness [J].

Gupta, A ;

Akin, D ;

Bashir, R .

APPLIED PHYSICS LETTERS, 2004, 84 (11) :1976-1978

[6] Vibrations of free and surface-coupled atomic force microscope cantilevers: Theory and experiment [J].

Rabe, U ;

Janser, K ;

Arnold, W .

REVIEW OF SCIENTIFIC INSTRUMENTS, 1996, 67 (09) :3281-3293

[7] Frequency response of cantilever beams immersed in viscous fluids with applications to the atomic force microscope [J].

Sader, JE .

JOURNAL OF APPLIED PHYSICS, 1998, 84 (01) :64-76

[8] Chemical sensors and biosensors in liquid environment based on microcantilevers with amplified quality factor [J].

Tamayo, J ;

Humphris, ADL ;

Malloy, AM ;

Miles, MJ .

ULTRAMICROSCOPY, 2001, 86 (1-2) :167-173

[9] THERMAL AND AMBIENT-INDUCED DEFLECTIONS OF SCANNING FORCE MICROSCOPE CANTILEVERS [J].

THUNDAT, T ;

WARMACK, RJ ;

CHEN, GY ;

ALLISON, DP .

APPLIED PHYSICS LETTERS, 1994, 64 (21) :2894-2896

[10] COVALENT ANCHORING OF PROTEINS ONTO GOLD-DIRECTED NHS-TERMINATED SELF-ASSEMBLED MONOLAYERS IN AQUEOUS BUFFERS - SFM IMAGES OF CLATHRIN CAGES AND TRISKELIA [J].

WAGNER, P ;

KERNEN, P ;

HEGNER, M ;

UNGEWICKELL, E ;

SEMENZA, G .

FEBS LETTERS, 1994, 356 (2-3) :267-271