Induction of apoptosis in vitro and in vivo by H-1 parvovirus infection

被引：39

作者：

Ohshima, T

Iwama, M

Ueno, Y

Sugiyama, F

Nakajima, T

Fukamizu, A

Yagami, K

机构：

[1] Univ Tsukuba, Inst Basic Med, Tsukuba, Ibaraki 3058575, Japan

[2] Univ Tsukuba, Lab Anim Res Ctr, Tsukuba, Ibaraki 3058575, Japan

[3] Univ Tsukuba, Inst Appl Biochem, Tsukuba, Ibaraki 3058575, Japan

来源：

JOURNAL OF GENERAL VIROLOGY | 1998年 / 79卷

关键词：

D O I：

10.1099/0022-1317-79-12-3067

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Apoptosis induced by H-1 parvovirus infection was investigated in C6 rat glioblastoma cells and in newborn rats. Apoptotic changes, such as chromatin condensation, the appearance of apoptotic nuclear bodies and oligonucleosomal DNA ladders, were observed in infected C6 cells 2 days after infection. Inhibitor assay results suggest that a caspase-3-dependent apoptosis activation pathway is induced by H-1 virus infection in C6 cells. Observations made in vivo revealed that the number of apoptotic cells increased in the infected cerebellum, coinciding with known virus infection sites.

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页码：3067 / 3071

页数：5

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