Antileukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb.

被引：103

作者：

Chang, JS ^{[1
]}

Chiang, LC ^{[1
]}

Chen, CC ^{[1
]}

Liu, LT ^{[1
]}

Wang, KC ^{[1
]}

Lin, CC ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2001年 / 29卷 / 02期

关键词：

D O I：

10.1142/S0192415X01000320

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

To evaluate the anti-leukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb., cytotoxicity tests with an XTT-based colorimetric assay were used. Five leukemic cell lines, namely L1210, U937, K562, Raji and P3HR1, were cultured with hot water extracts of B. pilosa var. minor or H. cordata. Hot water extracts of B. pilosa var. minor inhibited these five leukemic cells with IC(50)s between 145 mug/ml and 586 mug/ml. The effect was greatest on four cell lines, namely L1210, P3HR1, Raji and K562, with IC50s below 200 mug/ml. and a selective index of more than 5. Hot water extract of H. cordata inhibited these five leukemic cells with IC50s between 478 mug/ml and 662 mug/ml. The selective index was between 1.5 and 2.1. B. pilosa var. minor was more effective than H. cordata in inhibiting most of the leukemic cells in our study. We suggest that B. pilosa L. var. minor (Blume) Sherff may prove to be a useful medicinal plant for treating leukemia.

引用

页码：303 / 312

页数：10

共 21 条

[1] Gastric antisecretory and antiulcer activities of an ethanolic extract of Bidens pilosa L. var. radiata Schult. Bip. [J].

Alvarez, A ;

Pomar, F ;

Sevilla, MA ;

Montero, MJ .

JOURNAL OF ETHNOPHARMACOLOGY, 1999, 67 (03) :333-340

[2]

AMASON T, 1980, CAN J MICROBIOL, V26, P698

[3] Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds [J].

Brandao, MGL ;

Krettli, AU ;

Soares, LSR ;

Nery, CGC ;

Marinuzzi, HC .

JOURNAL OF ETHNOPHARMACOLOGY, 1997, 57 (02) :131-138

[4]

CARTER SK, 1976, CANCER TREAT REP, V60, P1141

[5]

CHANG RS, 1988, ANTIVIR RES, V9, P163, DOI 10.1016/0166-3542(88)90001-0

[6] The hepatoprotective effects of Taiwan folk medicine Ham-hong-chho in rats [J].

Chih, HW ;

Lin, CC ;

Tang, KS .

AMERICAN JOURNAL OF CHINESE MEDICINE, 1996, 24 (3-4) :231-240

[7] ANTIINFLAMMATORY ACTIVITY OF TAIWAN FOLK MEDICINE HAM-HONG-CHHO IN RATS [J].

CHIH, HW ;

LIN, CC ;

TANG, KS .

AMERICAN JOURNAL OF CHINESE MEDICINE, 1995, 23 (3-4) :273-278

[8] Hypotensive effects of a methanol extract from Bidens pilosa Linn on hypertensive rats [J].

Dimo, T ;

Nguelefack, TB ;

Kamtchouing, P ;

Dongo, É ;

Rakotonirina, A ;

Rakotonirina, SV .

COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES, 1999, 322 (04) :323-329

[9] Effects of leaf aqueous extract of Bidens pilosa (Asteraceae) on KCl- and norepinephrine-induced contractions of rat aorta [J].

Dimo, T ;

Rakotonirina, S ;

Kamgang, R ;

Tan, PV ;

Kamanyi, A ;

Bopelet, M .

JOURNAL OF ETHNOPHARMACOLOGY, 1998, 60 (02) :179-182

[10] SELECTIVITY AND POTENCY - ARE WE DOING THE RIGHT THINGS TO FIND ANTICANCER AGENTS WITH THESE PROPERTIES [J].

DOUBLE, JA .

BRITISH JOURNAL OF CANCER, 1992, 65 (02) :143-144

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