Non-oncogene addiction and the stress phenotype of cancer cells

被引：331

作者：

Solimini, Nicole L.

Luo, Ji

Elledge, Stephen J. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Genet & Genom,Howard Hughes Med Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Genet & Genom,Dept Genet, Boston, MA 02115 USA

来源：

CELL | 2007年 / 130卷 / 06期

关键词：

D O I：

10.1016/j.cell.2007.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Heat- shock factor 1 ( HSF1) is a transcription factor that is activated upon proteotoxic stress and coordinates induction of the heat- shock response. In this issue, Dai et al. ( 2007) show that HSF1 is a potent modifier of tumorigenesis and is required for tumor initiation and maintenance in a variety of cancer models. These findings add HSF1 to a growing list of non- oncogenes that could be exploited as cancer drug targets.

引用

页码：986 / 988

页数：3

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