TUMOR VOLUME AS PROGNOSTIC FACTOR IN CHEMORADIATION FOR ADVANCED HEAD AND NECK CANCER

被引：76

作者：

Knegjens, Joost L. ^{[1
]}

Hauptmann, Michael ^{[2
]}

Pameijer, Frank A. ^{[3
]}

Balm, Alfons J. ^{[4
,5
]}

Hoebers, Frank J. ^{[1
]}

de Bois, Josien A. ^{[1
]}

Kaanders, Johannes H. ^{[6
]}

van Herpen, Carla M. ^{[7
]}

Verhoef, Cornelia G. ^{[8
]}

Wijers, Oda B. ^{[9
]}

Wiggenraad, Ruud G. ^{[10
]}

Buter, Jan ^{[11
]}

Rasch, Coen R. ^{[1
]}

机构：

[1] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands

[2] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Bioinformat & Stat, Amsterdam, Netherlands

[3] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Radiol, Amsterdam, Netherlands

[4] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Head & Neck Oncol & Surg, Amsterdam, Netherlands

[5] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1105 AZ Amsterdam, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr, Dept Radiat Oncol, NL-6525 ED Nijmegen, Netherlands

[7] Radboud Univ Nijmegen, Med Ctr, Dept Med Oncol, NL-6525 ED Nijmegen, Netherlands

[8] Arnhem Radiotherapy Inst, Arnhem, Netherlands

[9] Radiotherapy Inst Friesland, Leeuwarden, Netherlands

[10] Haaglanden Med Ctr, Dept Radiat Oncol, The Hague, Netherlands

[11] Vrije Univ Amsterdam Med Ctr, Dept Med Oncol, Amsterdam, Netherlands

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2011年 / 33卷 / 03期

关键词：

head and neck cancer; radiotherapy; chemoradiation; tumor volume; prognostic factor; SQUAMOUS-CELL CARCINOMA; LOCAL-CONTROL; CONCURRENT CHEMORADIOTHERAPY; HYPOPHARYNGEAL CANCER; RADIATION-THERAPY; RANDOMIZED-TRIAL; DOSE CISPLATIN; PHASE-III; RADIOTHERAPY; CT;

D O I：

10.1002/hed.21459

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Tumor volume is an important predictor of outcome in radiotherapy alone. Its significance in concomitant chemoradiation (CCRT) is much less clear. We analyzed the prognostic value of primary tumor volume for advanced head and neck squamous cell carcinoma (HNSCC) treated with CCRT. Methods. Three hundred sixty patients treated with definitive CCRT for advanced HNSCC were selected. The pretreatment MRI or CT scan was used to calculate the primary tumor volume. Median follow-up was 19.8 months. Results. The average primary tumor volume was 37.0 cm(3) (range, 2.1-182.7 cm(3); median, 28.7 cm(3)). Multivariate analysis showed a significant effect of tumor volume on local control. The hazard ratio for a local recurrence increased by 14% per 10 cm(3) volume increase (95% CI, 8% to 21%). There was no significant independent effect of T and N status on local control. Conclusion. For advanced HNSCC, tumor volume is more powerful for predicting outcome after CCRT than TNM status. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 375-382, 2011

引用

页码：375 / 382

页数：8

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