Rad54, a Jack of all trades in homologous recombination

被引:118
作者
Tan, TLR
Kanaar, R
Wyman, C
机构
[1] Erasmus MC, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands
[2] Erasmus MC, Dept Radiat Oncol, NL-3000 DR Rotterdam, Netherlands
关键词
Rad54; Rad51; DNA double-strand break repair; chromatin remodeling; nucleosomes;
D O I
10.1016/S1568-7864(03)00070-3
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Homologous recombination mediates the transfer or exchange of genetic information between homologous DNA molecules. It plays important roles in central processes in the cell such as genome duplication and DNA damage repair. Recent experiments reveal the surprising versatility of one of its central actors, the Rad54 protein. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:787 / 794
页数:8
相关论文
共 27 条
[1]   Rad54 protein possesses chromatin-remodeling activity stimulated by the Rad51-ssDNA nucleoprotein filament [J].
Alexeev, A ;
Mazin, A ;
Kowalczykowski, SC .
NATURE STRUCTURAL BIOLOGY, 2003, 10 (03) :182-186
[2]   Strand pairing by Rad54 and Rad51 is enhanced by chromatin [J].
Alexiadis, V ;
Kadonaga, JT .
GENES & DEVELOPMENT, 2002, 16 (21) :2767-2771
[3]   Role of the human RAD51 protein in homologous recombination and double-stranded break repair [J].
Baumann, P ;
West, SC .
TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (07) :247-251
[4]   ATP-dependent nucleosomere modeling [J].
Becker, PB ;
Hörz, W .
ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :247-273
[5]   Recombinational repair in yeast: Functional interactions between Rad51 and Rad54 proteins [J].
Clever, B ;
Interthal, H ;
SchmuckliMaurer, J ;
King, J ;
Sigrist, M ;
Heyer, WD .
EMBO JOURNAL, 1997, 16 (09) :2535-2544
[6]   Homologous and non-homologous recombination differentially affect DNA damage repair in mice [J].
Essers, J ;
van Steeg, H ;
de Wit, J ;
Swagemakers, SMA ;
Vermeij, M ;
Hoeijmakers, JHJ ;
Kanaar, R .
EMBO JOURNAL, 2000, 19 (07) :1703-1710
[7]   Analysis of mouse Rad54 expression and its implications for homologous recombination [J].
Essers, J ;
Hendriks, RW ;
Wesoly, J ;
Beerens, CEMT ;
Smit, B ;
Hoeijmakers, JHJ ;
Wyman, C ;
Dronkert, MLG ;
Kanaar, R .
DNA REPAIR, 2002, 1 (10) :779-793
[8]   Disruption of mouse RAD54 reduces ionizing radiation resistance [J].
Essers, J ;
Hendriks, RW ;
Swagemakers, SMA ;
Troelstra, C ;
deWit, J ;
Bootsma, D ;
Hoeijmakers, JHJ ;
Kanaar, R .
CELL, 1997, 89 (02) :195-204
[9]   Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage [J].
Essers, J ;
Houtsmuller, AB ;
van Veelen, L ;
Paulusma, C ;
Nigg, AL ;
Pastink, A ;
Vermeulen, W ;
Hoeijmakers, JHJ ;
Kanaar, R .
EMBO JOURNAL, 2002, 21 (08) :2030-2037
[10]   Interaction of human recombination proteins Rad51 and Rad54 [J].
Golub, EI ;
Kovalenko, OV ;
Gupta, RC ;
Ward, DC ;
Radding, CM .
NUCLEIC ACIDS RESEARCH, 1997, 25 (20) :4106-4110