Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis

被引：72

作者：

Goldbach-Mansky, R

Lee, JM

Hoxworth, JM

Smith, D

Duray, P

Schumacher, HR

Yarboro, CH

Klippel, J

Kleiner, D

El-Gabalawy, HS

机构：

[1] NIAMSD, Arthrit & Rheumatism Branch, NIH, Bethesda, MD 20892 USA

[2] NIH, Dept Pathol, Bethesda, MD 20892 USA

[3] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[4] Vet Affairs, Philadelphia, PA USA

来源：

ARTHRITIS RESEARCH | 2000年 / 2卷 / 02期

关键词：

early synovitis; erosion; metalloproteinase; matrix metalloproteinase-2; rheumatoid arthritis;

D O I：

10.1186/ar79

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients. Immunohistological staining of MMP-2, MMP-14 and TIMP-2 localized to corresponding areas in the synovial lining layer and was almost absent in normal synovium. Patients with radiographic erosions had significantly higher levels of active MMP-2 than patients with no erosions, suggesting that activated MMP-2 levels in synovial tissue may be a marker for a more aggressive synovial lesion.

引用

页码：145 / 153

页数：9

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