A genomic screen of Spanish multiple sclerosis patients reveals multiple loci associated with the disease

被引：33

作者：

Goertsches, R

Villoslada, P

Comabella, M

Montalban, X

Navarro, A

de la Concha, EG

Arroyo, R

de Munain, AL

Otaegui, D

Palacios, R

Perez-Tur, J

Jonasdottir, A

Benediktsson, K

Fossdal, R

Sawcer, S

Setakis, E

Compston, A

机构：

[1] Clin Univ Navarra, Lab Neuroimmunol, Dept Neurol, Pamplona 31008, Spain

[2] Hosp Valle De Hebron, Neuroimmunol Unit, Barcelona, Spain

[3] Univ Pompeu Fabra, Unitat Biol Evolut, Barcelona, Spain

[4] Hosp Clin San Carlos, Dept Immunol & Neurol, Madrid, Spain

[5] Hosp Donostia, Dept Neurol, San Sebastian, Spain

[6] CSIC, Inst Biomed Valencia, Valencia, Spain

[7] deCODE Inc, Reykjavik, Iceland

[8] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

[9] Inst Publ Hlth, MRC Biostat Unit, Cambridge, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 143卷 / 1-2期

关键词：

GAMES; multiple sclerosis; linkage disequilibrium; genomic screen; DNA pooling;

D O I：

10.1016/j.jneuroim.2003.08.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to identify the genomic regions that might confer susceptibility to multiple sclerosis (MS) in the Spanish population, we have performed a genome-wide screen for association in patients with MS using pooled DNA from 200 clinical cases and 200 healthy controls. The pools were typed using 5546 microsatellites. The typing was repeated for the most promising 1269 markers after which 191 potentially associated markers were identified. Eleven of these markers map to the MHC region, and 14 to non-MHC regions identified in previous linkage screens. Our results provide support for the presence of multiple coding regions that contain MS susceptibility genes of small or moderate effect. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：124 / 128

页数：5

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