The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi

被引：58

作者：

Gabel, Harrison W.

Ruvkun, Gary ^{[1
]}

机构：

[1] Harvard Med Sch, Dept Genet, Boston, MA 02114 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2008年 / 15卷 / 05期

关键词：

D O I：

10.1038/nsmb.1411

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The exonuclease ERI-1 negatively regulates RNA interference in Caenorhabditis elegans and Schizosaccharomyces pombe, and is required for production of some C. elegans endogenous small interfering RNAs. We show that ERI-1 performs 3' end processing of the 5.8S ribosomal RNA in both C. elegans and S. pombe. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference.

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页码：531 / 533

页数：3

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