Role of angiocrine signals in bone development, homeostasis and disease

被引：50

作者：

Sivan, Unnikrishnan ^{[1
]}

De Angelis, Jessica ^{[1
]}

Kusumbe, Anjali P. ^{[1
]}

机构：

[1] Univ Oxford, Kennedy Inst Rheumatol, Oxford OX3 7FY, England

来源：

OPEN BIOLOGY | 2019年 / 9卷 / 10期

基金：

英国医学研究理事会; 欧洲研究理事会;

关键词：

angiogenesis; bone marrow niche; osteogenesis; repair; regeneration; ENDOTHELIAL GROWTH-FACTOR; HEMATOPOIETIC STEM-CELLS; HYPOXIA-INDUCIBLE FACTOR; VASCULAR NICHE; RHEUMATOID-ARTHRITIS; PROGENITOR CELLS; GENE-EXPRESSION; MESSENGER-RNA; MARROW NICHE; SELF-RENEWAL;

D O I：

10.1098/rsob.190144

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Skeletal vasculature plays a central role in the maintenance of microenvironments for osteogenesis and haematopoiesis. In addition to supplying oxygen and nutrients, vasculature provides a number of inductive factors termed as angiocrine signals. Blood vessels drive recruitment of osteoblast precursors and bone formation during development. Angiogenesis is indispensable for bone repair and regeneration. Dysregulation of the angiocrine crosstalk is a hallmark of ageing and pathobiological conditions in the skeletal system. The skeletal vascular bed is complex, heterogeneous and characterized by distinct capillary subtypes (type H and type L), which exhibit differential expression of angiocrine factors. Furthermore, distinct blood vessel subtypes with differential angiocrine profiles differentially regulate osteogenesis and haematopoiesis, and drive disease states in the skeletal system. This review provides an overview of the role of angiocrine signals in bone during homeostasis and disease.

引用

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