Cyclin E in normal and neoplastic cell cycles

被引：399

作者：

Hwang, HC

Clurman, BE

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA

[2] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

[3] Univ Washington, Sch Med, Dept Med, Seattle, WA 98104 USA

来源：

ONCOGENE | 2005年 / 24卷 / 17期

关键词：

cyclin E; Cdk; cell cycle; tumorigenesis;

D O I：

10.1038/sj.onc.1208613

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclin E- Cdk2 has long been considered an essential and master regulator of progression through G1 phase of the cell cycle. Although recent mouse models have prompted a rethinking of cyclin E function in mammals, it remains clear that cyclin E impacts upon many processes central to cell division. Normal cells maintain strict control of cyclin E activity, and this is commonly disrupted in cancer cells. Moreover, cyclin E deregulation is thought to play a fundamental role in tumorigenesis. In this review, we discuss the regulation and functions of cyclin E in normal and neoplastic mammalian cells.

引用

收藏

页码：2776 / 2786

页数：11

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