Copper-mediated selective oxidation of a C-H bond

被引：40

作者：

Boldron, C

Gamez, P

Tooke, DM

Spek, AL

Reedijk, J

机构：

[1] Leiden Univ, Leiden Inst Chem, Gorlaeus Labs, NL-2300 RA Leiden, Netherlands

[2] Univ Utrecht, Dept Crystal & Struct Chem, NL-3584 CH Utrecht, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 23期

关键词：

biomimetic synthesis; C-H activation; copper; homogeneous catalysis; oxidation;

D O I：

10.1002/anie.200462946

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) An environmentally friendly procedure has been developed for the oxidation of 2,4,6-trimethylpheriol (TMP) at the para Csp3-H bond. Upon reaction with H2O2 in the presence of catalytic amounts of CuII and neocuproine in methanol at 65°C, 4-(methoxymethyl)-2,6-dimethylphenol (MDP) or 4-hydroxy-3,5- dimethylbenzaldehyde (HDB) is formed (see reaction). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：3585 / 3587

页数：3

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