Versatility of Aminoglycosides and prospects for their future

被引：448

作者：

Vakulenko, SB

Mobashery, S

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

[2] Wayne State Univ, Dept Pharmacol, Detroit, MI 48202 USA

[3] Wayne State Univ, Dept Mol Biol, Detroit, MI 48202 USA

来源：

CLINICAL MICROBIOLOGY REVIEWS | 2003年 / 16卷 / 03期

关键词：

D O I：

10.1128/CMR.16.3.430-450.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aminoglycoside antibiotics have had a major impact on our ability to treat bacterial infections for the past half century. Whereas the interest in these versatile antibiotics continues to be high, their clinical utility has been compromised by widespread instances of resistance. The multitude of mechanisms of resistance is disconcerting but also illuminates how nature can manifest resistance when bacteria are confronted by antibiotics. This article reviews the most recent knowledge about the mechanisms of aminoglycoside action and the mechanisms of resistance to these antibiotics.

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页码：430 / +

页数：22

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