Versatility of Aminoglycosides and prospects for their future

被引：448

作者：

Vakulenko, SB

Mobashery, S

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

[2] Wayne State Univ, Dept Pharmacol, Detroit, MI 48202 USA

[3] Wayne State Univ, Dept Mol Biol, Detroit, MI 48202 USA

来源：

CLINICAL MICROBIOLOGY REVIEWS | 2003年 / 16卷 / 03期

关键词：

D O I：

10.1128/CMR.16.3.430-450.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aminoglycoside antibiotics have had a major impact on our ability to treat bacterial infections for the past half century. Whereas the interest in these versatile antibiotics continues to be high, their clinical utility has been compromised by widespread instances of resistance. The multitude of mechanisms of resistance is disconcerting but also illuminates how nature can manifest resistance when bacteria are confronted by antibiotics. This article reviews the most recent knowledge about the mechanisms of aminoglycoside action and the mechanisms of resistance to these antibiotics.

引用

收藏

页码：430 / +

页数：22

相关论文

共 324 条

[41] Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021 [J].

Capela, D ;

Barloy-Hubler, F ;

Gouzy, J ;

Bothe, G ;

Ampe, F ;

Batut, J ;

Boistard, P ;

Becker, A ;

Boutry, M ;

Cadieu, E ;

Dréano, S ;

Gloux, S ;

Godrie, T ;

Goffeau, A ;

Kahn, D ;

Kiss, E ;

Lelaure, V ;

Masuy, D ;

Pohl, T ;

Portetelle, D ;

Pühler, A ;

Purnelle, B ;

Ramsperger, U ;

Renard, C ;

Thébault, P ;

Vandenbol, M ;

Weidner, S ;

Galibert, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (17) :9877-9882

[42] Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998 [J].

Carattoli, A ;

Tosini, F ;

Giles, WP ;

Rupp, ME ;

Hinrichs, SH ;

Angulo, FJ ;

Barrett, TJ ;

Fey, PD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (05) :1269-1272

[43] EMERGENCE OF 4',4''-AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE IN ENTEROCOCCI [J].

CARLIER, C ;

COURVALIN, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (08) :1565-1569

[44] Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics [J].

Carter, AP ;

Clemons, WM ;

Brodersen, DE ;

Morgan-Warren, RJ ;

Wimberly, BT ;

Ramakrishnan, V .

NATURE, 2000, 407 (6802) :340-348

[45] Characterization of the 6′-N-aminoglycoside acetyltransferase gene aac(6′)-Iq from the integron of a natural multiresistance plasmid [J].

Centrón, D ;

Roy, PH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (06) :1506-1508

[46] Presence of a group II intron in a multiresistant Serratia marcescens strain that harbors three integrons and a novel gene fusion [J].

Centrón, D ;

Roy, PH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (05) :1402-1409

[47] DETECTION OF APRAMYCIN RESISTANT ENTEROBACTERIACEAE IN HOSPITAL ISOLATES [J].

CHASLUSDANCLA, E ;

GLUPCZYNSKI, Y ;

GERBAUD, G ;

LAGORCE, M ;

LAFONT, JP ;

COURVALIN, P .

FEMS MICROBIOLOGY LETTERS, 1989, 61 (03) :261-266

[48]

CHINAULT AC, 1986, PLASMID, V15, P119, DOI 10.1016/0147-619X(86)90048-X

[49] NUCLEOTIDE-SEQUENCE ANALYSIS OF A TRANSPOSON (TN5393) CARRYING STREPTOMYCIN RESISTANCE GENES IN ERWINIA-AMYLOVORA AND OTHER GRAM-NEGATIVE BACTERIA [J].

CHIOU, CS ;

JONES, AL .

JOURNAL OF BACTERIOLOGY, 1993, 175 (03) :732-740

[50] Aminoglycoside resistance in enterococci [J].

Chow, JW .

CLINICAL INFECTIOUS DISEASES, 2000, 31 (02) :586-589

← 1 2 3 4 5 6 7 8 9 10 →