Mild Cognitive Impairment

被引：970

作者：

Petersen, Ronald C. ^{[1
,2
]}

机构：

[1] Mayo Clin, Dept Neurol, Coll Med, Rochester, MN 55905 USA

[2] Mayo Clin, Alzheimers Dis Res Ctr, Rochester, MN 55905 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2011年 / 364卷 / 23期

关键词：

ALZHEIMERS-DISEASE; CSF BIOMARKERS; CLINICAL CHARACTERIZATION; AMYLOID DEPOSITION; AMERICAN-ACADEMY; FOLLOW-UP; DEMENTIA; PREVALENCE; PROGRESSION; PREDICTION;

D O I：

10.1056/NEJMcp0910237

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 70-year-old woman has been noticing increasing forgetfulness over the past 6 to 12 months. Although she has always had some difficulty recalling the names of acquaintances, she is now finding it difficult to keep track of appointments and recent telephone calls, but the process has been insidious. She lives independently in the community; she drives a car, pays her bills, and is normal in appearance. A mental status examination revealed slight difficulty on delayed recall of four words, but the results were otherwise normal. Does the patient have mild cognitive impairment? How should her case be managed?

引用

页码：2227 / 2234

页数：8

共 52 条

[1]

ALBERT MS, 2011, ALZHEIMERS DEME 0420

[2]

Apostolova LG, 2007, ARCH NEUROL-CHICAGO, V64, P1360

[3] Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps [J].

Apostolova, Liana G. ;

Dutton, Rebecca A. ;

Dinov, Ivo D. ;

Hayashi, Kiralee M. ;

Toga, Arthur W. ;

Cummings, Jeffrey L. ;

Thompson, Paul M. .

ARCHIVES OF NEUROLOGY, 2006, 63 (05) :693-699

[4] Mild cognitive impairment -: Long-term course of four clinical subtypes [J].

Busse, A. ;

Hensel, A. ;

Guehne, U. ;

Angermeyer, M. C. ;

Riedel-Heller, S. G. .

NEUROLOGY, 2006, 67 (12) :2176-2185

[5] Mild cognitive impairment -: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease? [J].

Chételat, G ;

Desgranges, B ;

de la Sayette, V ;

Viader, F ;

Eustache, F ;

Baron, JC .

NEUROLOGY, 2003, 60 (08) :1374-1377

[6] Diagnosis-Independent Alzheimer Disease Biomarker Signature in Cognitively Normal Elderly People [J].

De Meyer, Geert ;

Shapiro, Fred ;

Vanderstichele, Hugo ;

Vanmechelen, Eugeen ;

Engelborghs, Sebastiaan ;

De Deyn, Peter Paul ;

Coart, Els ;

Hansson, Oskar ;

Minthon, Lennart ;

Zetterberg, Henrik ;

Blennow, Kaj ;

Shaw, Leslie ;

Trojanowski, John Q. .

ARCHIVES OF NEUROLOGY, 2010, 67 (08) :949-956

[7] CIND and MCI in the Italian elderly - Frequency, vascular risk factors, progression to dementia [J].

Di Carlo, A. ;

Lamassa, M. ;

Baldereschi, M. ;

Inzitari, M. ;

Scafato, E. ;

Farchi, G. ;

Inzitari, D. .

NEUROLOGY, 2007, 68 (22) :1909-1916

[8] Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment [J].

Dickerson, Bradford C. ;

Sperling, Reisa A. ;

Hyman, Bradley T. ;

Albert, Marilyn S. ;

Blacker, Deborah .

ARCHIVES OF GENERAL PSYCHIATRY, 2007, 64 (12) :1443-1450

[9] Donepezil treatment of patients with MCI A 48-week randomized, placebo-controlled trial [J].

Doody, R. S. ;

Ferris, S. H. ;

Salloway, S. ;

Sun, Y. ;

Goldman, R. ;

Watkins, W. E. ;

Xu, Y. ;

Murthy, A. K. .

NEUROLOGY, 2009, 72 (18) :1555-1561

[10]

Drzezga A, 2005, J NUCL MED, V46, P1625

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