Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI

被引：247

作者：

Choe, R

Corlu, A

Lee, K

Durduran, T

Konecky, SD

Grosicka-Koptyra, M

Arridge, SR

Czerniecki, BJ

Fraker, DL

DeMichele, A

Chance, B

Rosen, MA

Yodh, AG

机构：

[1] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA

[2] UCL, Dept Comp Sci, London WC1E 6BT, England

[3] Hosp Univ Penn, Dept Surg, Philadelphia, PA 19104 USA

[4] Hosp Univ Penn, Dept Med Heme Onc, Philadelphia, PA 19104 USA

[5] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

来源：

MEDICAL PHYSICS | 2005年 / 32卷 / 04期

关键词：

diffuse optical tomography; neoadjuvant chemotherapy; breast cancer; near infrared imaging; breast imaging;

D O I：

10.1118/1.1869612

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three-dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measurements reveal tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy. (c) 2005 American Association of Physicists in Medicine.

引用

页码：1128 / 1139

页数：12

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