Directing the differentiation of embryonic stem cells to neural stem cells

被引：62

作者：

Cai, Chunyu ^{[1
]}

Grabel, Laura ^{[1
]}

机构：

[1] Wesleyan Univ, Dept Biol, Middletown, CT 06459 USA

来源：

DEVELOPMENTAL DYNAMICS | 2007年 / 236卷 / 12期

关键词：

embryonic stem cells; neural stem cells; neural progenitors; Notch; Hedgehog; Wnt; VEGF; FGF;

D O I：

10.1002/dvdy.21306

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Embryonic stem cells (ESCs) are a potential source of neural derivatives that can be used in stem cell-based therapies designed to treat neurological disorders. The derivation of specific neuronal or glial cell types from ESCs invariably includes the production of neural stem cells (NSCs). We describe the basic mechanisms of neural induction during vertebrate embryogenesis and how this information helped formulate several protocols used to generate NSCs from ESCs. We highlight the advantages and disadvantages of each approach and review what has been learned about the intermediate stages in the transition from ESC to NSC. Recent data describing how specific growth factors and signaling molecules regulate production of NSCs are described and a model synthesizing this information is presented. Developmental Dynamics 236:3255-3266, 2007. (c) 2007 Wiley-Liss, Inc.

引用

页码：3255 / 3266

页数：12

共 109 条

[71]

Rathjen J, 2002, DEVELOPMENT, V129, P2649

[72] Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell [J].