Counting the SNAREs needed for membrane fusion

被引：24

作者：

van den Bogaart, Geert ^{[1
]}

Jahn, Reinhard ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Dept Neurobiol, D-37077 Gottingen, Germany

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2011年 / 3卷 / 04期

关键词：

VESICLE FUSION; COMPLEXES;

D O I：

10.1093/jmcb/mjr004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SNARE proteins mediate most membrane fusion reactions in eukaryotic cells, and are thereby vital for many functions, including synaptic transmission, cell growth, and cytokinesis. However, until recently it was still unclear how many of these proteins are required to catalyze membrane fusion in vivo. In a recent Science paper, Mohrmann et al. (2010) elegantly show that in chromaffin cells, three SNARE complexes are required for the synchronous release of granules, whereas only a single SNARE complex is sufficient for overall release.

引用

页码：204 / 205

页数：2

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