Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage 'in cellulo'

被引:109
作者
Poole, RA
Bobba, G
Cann, MJ
Frias, JC
Parker, D
Peacock, RD
机构
[1] Univ Durham, Dept Chem, Durham DH1 3LE, England
[2] Univ Durham, Dept Biol Sci, Durham DH1 3LE, England
[3] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland
关键词
D O I
10.1039/b418964g
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis and photophysical characterisation are reported of a series of cationic, neutral and anionic europium and terbium complexes based on structurally related, nonadentate ligands based on the cyclen macrocycle. Each complex incorporates a tetraazatriphenylene moiety and overall absolute emission quantum yields are in the range 15 - 40% in aerated aqueous media. Dynamic quenching of the lanthanide excited state occurs with electron-rich donors, e. g. iodide, ascorbate and urate, and a mechanistic interpretation is put forward involving an electron transfer process. The cationic lanthanide complexes are taken up by N1H/ 3T3 cells and tend to localise inside the cell nucleus.
引用
收藏
页码:1013 / 1024
页数:12
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