Photochemical and pharmacological aspects of nitric oxide release from some nitrosyl ruthenium complexes entrapped in sol-gel and silicone matrices

被引：15

作者：

de Lima, Renata Galvdo

Sauaia, Marilia Gama

Ferezin, Camila

Pepe, Luri Muniz

Jose, Nadia Mamede

Bendhack, Lusiane M.

da Rocha, Zenis Novais

da Silva, Roberto Santana

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-14040903 Ribeirao Preto, Brazil

[2] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, Brazil

[3] Univ Fed Bahia, Opt Properties Lab, Inst Fis, LaPO, Salvador, BA, Brazil

[4] Univ Fed Bahia, Inst Quim, Salvador, BA, Brazil

来源：

POLYHEDRON | 2007年 / 26卷 / 16期

基金：

巴西圣保罗研究基金会;

关键词：

immobilized ruthenium complexes; nitric oxide; photo-release;

D O I：

10.1016/j.poly.2007.03.042

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The entrapped [Ru(terpy)(L)NO](PF6)(3), where terpy = 2,2':6',2"-terpyridine and L = 2,2'-bipyridine (bpy) and 3,4-diiminebenzoic acid (NH center dot NHq) complexes into sol-gel processed polysiloxane and silicone matrices, shows NO release characteristics when submitted to light irradiation at 355 and 532 nm, as judged by NO measurement using a NO-sensor electrode. The pharmacological properties of doped matrix showed vasodilator characteristics by visible light irradiation, which is of great interest because the target delivery system can avoid the occurrence of side effects possibly by the aquo ruthenium specie. All matrices obtained showed to be amorphous materials. The scanning electron micrographs of the matrices showed irregularly shaped particles, with broad size of 1000 mu m for both matrices and homogeneous distribution. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4620 / 4624

页数：5

共 27 条

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