Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus

被引：27

作者：

Auclair, K

Kennedy, J

Hutchinson, CR

Vederas, JC ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

[2] Univ Wisconsin, Sch Pharm, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

[4] Kosan Biosci Inc, Hayward, CA 94545 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 12期

基金：

加拿大自然科学与工程研究理事会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(01)00290-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Investigation of the post-PKS biosynthetic steps to the cholesterol-lowering agent lovastatin (1) using an Aspergillus terreus strain with a disrupted lovC gene, which is essential for formation of 4a,5-dihydromonacolin L (3), shows that 7 and 3 are precursors to 1, and demonstrates that lovastatin diketide synthase (lovF protein) does not require lovC. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1527 / 1531

页数：5

共 23 条

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