Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells

被引：128

作者：

Levy, O

Orange, JS

Hibberd, P

Steinberg, S

LaRussa, P

Weinberg, A

Wilson, SB

Shaulov, A

Fleisher, G

Geha, RS

Bonilla, FA

Exley, M

机构：

[1] Univ Colorado, Hlth Sci Ctr, Denver, CO USA

[2] Columbia Univ, Coll Phys & Surg, New York, NY USA

[3] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Massachusetts Gen Hosp, Cardiac Unit, Diabet Unit, Boston, MA 02114 USA

[6] Harvard Univ, Childrens Hosp, Sch Med, Div Emergency Med, Boston, MA 02115 USA

[7] Harvard Univ, Childrens Hosp, Sch Med, Div Immunol, Boston, MA 02115 USA

[8] Harvard Univ, Childrens Hosp, Sch Med, Div Infect Dis, Boston, MA 02115 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2003年 / 188卷 / 07期

关键词：

D O I：

10.1086/378503

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An 11-year-old girl presented with a papulovesicular rash and severe respiratory distress 5 weeks after receiving varicella vaccine. Restriction fragment length - polymorphism analysis of virus isolated from an endotracheal-tube aspirate and from bronchoalveolar lavage revealed that this patient's illness was due to the Oka vaccine strain of varicella. An extensive immunologic analysis failed to identify a known diagnostic entity to explain her susceptibility to this attenuated vaccine strain. Analysis of her lymphocytes on separate occasions, months after recovery from her illness, revealed a profound deficiency of natural killer T (NKT) cells and of NKT-cell activity, suggesting that NKT cells contribute to host defense against varicella virus.

引用

页码：948 / 953

页数：6

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