Trypanocidal constituents in plants 3.: Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense

被引:61
作者
Abe, F
Nagafuji, S
Okabe, H
Akahane, H
Estrada-Muñiz, E
Huerta-Reyes, M
Reyes-Chilpa, R
机构
[1] Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan
[2] Fukuoka Univ, Sch Med, Jonan Ku, Fukuoka 8140180, Japan
[3] Natl Autonomous Univ Mexico, Inst Chem, Mexico City 04510, DF, Mexico
关键词
Trypanosoma cruzi; Garcinia intermedia; Calophyllum brasiliense; trypanocidal activity; Chagas' disease; Guttiferae;
D O I
10.1248/bpb.27.141
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The constituents of the leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense were investigated based on their trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent of Chagas' disease. As the active components, the polyisoprenylated benzophenone derivative guttiferone A and the xanthone 8-desoxygartanin were isolated along with the biflavonoids podocarpusfiavone A and amentoflavone, and friedelin from the former. Three xanthones, jacareubin, 6-deoxyjacareubin, and 1,3,5,6-tetrahydroxy-2-(3-methyl-2-butenyl)xanthone from the latter showed activity. The trypanocidal activity of these compounds against trypomastigotes, an infectious form of T cruzi, was examined as well as gossypol, berberine chloride, and harmine for comparison.
引用
收藏
页码:141 / 143
页数:3
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