Signal transduction of bone morphogenetic protein receptors

被引：431

作者：

Nohe, A ^{[1
]}

Keating, E

Knaus, P

Petersen, NO

机构：

[1] Univ Western Ontario, Dept Chem, London, ON N6A 1B7, Canada

[2] Univ Wurzburg, Dept Physiol Chem 2, D-97074 Wurzburg, Germany

来源：

CELLULAR SIGNALLING | 2004年 / 16卷 / 03期

关键词：

BMP receptors; Smad; p38; map kinase pathway;

D O I：

10.1016/j.cellsig.2003.08.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bone morphogenetic proteins (BMPs) play a crucial role during all stages of embryonic development. Although only two major signaling pathways have been characterized (the p38 and Smad pathways), the BMP signaling is complex and includes several negative feedback mechanisms. This article reviews the current state of BMP receptor signaling and provides a summary of the crosstalk of the BMP receptor pathway with other major signaling pathways. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：291 / 299

页数：9

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