Physiology and Pathology of Endosome-to-Golgi Retrograde Sorting

被引：56

作者：

Burd, Christopher G. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

来源：

TRAFFIC | 2011年 / 12卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; Charcot-Marie-Tooth disease; development; endocytosis; endosome; hereditary spastic paraplegia; retrograde; retromer; secretion; sorting; trans-Golgi network; AMYLOID PRECURSOR PROTEIN; HEAVY-CHAIN ISOFORM; WNT-PRODUCING CELLS; RETROMER COMPLEX; ALZHEIMERS-DISEASE; TRANSPORT; RECEPTOR; RETRIEVAL; REQUIRES; NETWORK;

D O I：

10.1111/j.1600-0854.2011.01188.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bidirectional traffic between the Golgi apparatus and the endosomal system sustains the functions of the trans-Golgi network (TGN) in secretion and organelle biogenesis. Export of cargo from the TGN via anterograde trafficking pathways depletes the organelle of sorting receptors, processing proteases, SNARE molecules, and other factors, and these are subsequently retrieved from endosomes via the retrograde pathway. Recent studies indicate that retrograde trafficking is vital to early metazoan development, nutrient homeostasis, and for processes that protect against Alzheimer's and other neurological diseases.

引用

页码：948 / 955

页数：8

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