Micro/nanostructured polymeric systems for biomedical and pharmaceutical applications

被引：80

作者：

Chiellini, Federica ^{[1
]}

Piras, Anna Maria ^{[1
]}

Errico, Cesare ^{[1
]}

Chiellini, Emo ^{[1
]}

机构：

[1] Univ Pisa, Dept Chem & Ind Chem, UdR INSTM, Lab Bioact Polymer Mat Biomed Environm Applicat, I-56010 Pisa, Italy

来源：

NANOMEDICINE | 2008年 / 3卷 / 03期

关键词：

biocompatible polymers; biomedical applications; drug delivery; nanomedicine; polymeric nanoparticles;

D O I：

10.2217/17435889.3.3.367

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This review provides an outline of the polymeric micro/nanostructured advanced systems that are suited for the controlled and targeted administration of, specifically, nonconventional drugs. The contribution of new trends in drug-delivery technology is focused on two major parts, dealing with brief surveys of: the biodegradable/bioerodible polymeric systems used in the formulation of micro/nanoparticles and techniques used in the preparation of micro/nanoparticles for their biomedical application in cancer treatment specifically, in inflammation pathologies, as oxygen carriers (blood substitutes) and in tissue-engineering practice. A small discussion of the future perspectives of the described systems is also given.

引用

页码：367 / 393

页数：27

共 240 条

[151] Novel powder formulations for controlled delivery of poorly soluble anticancer drug: Application and investigation of TPGS and PEG in spray-dried particulate system [J].