Combinatorial biosynthesis of reduced polyketides

被引：333

作者：

Weissman, KJ ^{[1
]}

Leadlay, PF ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 12期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nrmicro1287

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The bacterial multienzyme polyketide synthases (PKSs) produce a diverse array of products that have been developed into medicines, including antibiotics and anticancer agents. The modular genetic architecture of these PKSs suggests that it might be possible to engineer the enzymes to produce novel drug candidates, a strategy known as `combinatorial biosynthesis'. So far, directed engineering of modular PKSs has resulted in the production of more than 200 new polyketides, but key challenges remain before the potential of combinatorial biosynthesis can be fully realized.

引用

页码：925 / 936

页数：12

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