Metabotropic glutamate receptors in the basal ganglia motor circuit

被引：259

作者：

Conn, PJ

Battaglia, G

Marino, MJ

Nicoletti, F

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Program Translat Neuropharmacol, Nashville, TN 37232 USA

[2] Neuromed, Inst Neurol Mediterraneo, Dept Neuropharmacol, I-86077 Pozzilli, Italy

[3] Merck Res Labs, Movement Disorders, Neurosci Drug Discovery, West Point, PA 19486 USA

[4] Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, I-00185 Rome, Italy

来源：

NATURE REVIEWS NEUROSCIENCE | 2005年 / 6卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrn1763

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In recent years there have been tremendous advances in our understanding of the circuitry of the basal ganglia and our ability to predict the behavioural effects of specific cellular changes in this circuit on voluntary movement. These advances, combined with a new understanding of the rich distribution and diverse physiological roles of metabotropic glutamate receptors in the basal ganglia, indicate that these receptors might have a key role in motor control and raise the exciting possibility that they might provide therapeutic targets for the treatment of Parkinson's disease and related disorders.

引用

收藏

页码：787 / 798

页数：12

相关论文

共 147 条

[1] Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP [J].

Aguirre, JA ;

Kehr, J ;

Yoshitake, T ;

Liu, FL ;

Rivera, A ;

Fernandez-Espinola, S ;

Andbjer, B ;

Leo, G ;

Medhurst, AD ;

Agnati, LF ;

Fuxe, K .

BRAIN RESEARCH, 2005, 1033 (02) :216-220

[2] Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems [J].

Alagarsamy, S ;

Marino, MJ ;

Rouse, ST ;

Gereau, RW ;

Heinemann, SF ;

Conn, PJ .

NATURE NEUROSCIENCE, 1999, 2 (03) :234-240

[3] NMDA-induced phosphorylation and regulation of mGluR5 [J].

Alagarsamy, S ;

Rouse, ST ;

Junge, C ;

Hubert, GW ;

Gutman, D ;

Smith, Y ;

Conn, PJ .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 73 (02) :299-306

[4] QUISQUALATE METABOTROPIC RECEPTORS MODULATE NMDA CURRENTS AND FACILITATE INDUCTION OF LONG-TERM POTENTIATION THROUGH PROTEIN-KINASE-C [J].

ANIKSZTEJN, L ;

OTANI, S ;

BENARI, Y .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1992, 4 (06) :500-505

[5]

Awad H, 2000, J NEUROSCI, V20, P7871

[6] Activation of groups I or III metabotropic glutamate receptors inhibits excitatory transmission in the rat subthalamic nucleus [J].

Awad-Granko, H ;

Conn, PJ .

NEUROPHARMACOLOGY, 2001, 41 (01) :32-41

[7]

Baker DA, 2002, J NEUROSCI, V22, P9134

[8] In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats [J].

Battaglia, G ;

Monn, JA ;

Schoepp, DD .

NEUROSCIENCE LETTERS, 1997, 229 (03) :161-164

[9] Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice [J].

Battaglia, G ;

Busceti, CL ;

Pontarelli, F ;

Biagioni, F ;

Fornai, F ;

Paparelli, A ;

Bruno, V ;

Ruggieri, S ;

Nicoletti, F .

NEUROPHARMACOLOGY, 2003, 45 (02) :155-166

[10] Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity [J].

Battaglia, G ;

Fornai, F ;

Busceti, CL ;

Aloisi, G ;

Cerrito, F ;

De Blasi, A ;

Melchiorri, D ;

Nicoletti, F .

JOURNAL OF NEUROSCIENCE, 2002, 22 (06) :2135-2141

← 1 2 3 4 5 6 7 8 9 10 →