DC homeostasis in hematopoietic stem cell transplantation

被引：7

作者：

Collin, M. P. ^{[1
]}

Bogunovic, M. ^{[1
]}

Merad, M. ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

来源：

CYTOTHERAPY | 2007年 / 9卷 / 06期

关键词：

stem cell transplantation; dendritic cell; homeostasis; graft versus host disease;

D O I：

10.1080/14653240701507314

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Hematopoietic stem cell transplantation is an important experimental tool and therapeutic modality. Its efficacy and toxicity are both linked to a GvH reaction that is initiated by donor T cells recognizing recipient APC, of which DC are the most potent. In most tissues recipient DC are replaced after transplantation because they turnover rapidly from BM-derived precursors. However, in a number of sites, notably the skin, recipient DC may persist and even self-renew for many months after transplantation. Understanding the homeostasis of different APC populations and how they are related to the induction of alloreactivity may help to improve the therapeutic benefit of transplantation.

引用

页码：521 / 531

页数：11

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