Recent advances in the controlled preparation of poly(α-hydroxy acids):: Metal-free catalysts and new monomers

被引：148

作者：

Bourissou, Didier ^{[1
]}

Moebs-Sanchez, Sylvie ^{[1
]}

Martin-Vaca, Blance ^{[1
]}

机构：

[1] Univ Toulouse 3, CNRS, UMR 5069, Lab Heterochim Fondamentale & Appl, F-31062 Toulouse 09, France

来源：

COMPTES RENDUS CHIMIE | 2007年 / 10卷 / 09期

关键词：

a-hydroxy acids; organocatalysis; enzymatic catalysis; 1,4-Dioxane-2,5-diones; O-Carboxy anhydrides;

D O I：

10.1016/j.crci.2007.05.004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polylactides (PLAs) are at the forefront of biodegradable polymer research. These poly(alpha-hydroxy acids) can be prepared by polycondensation of lactic acid or ring-opening polymerization (ROP) of lactide, both routes typically involving metallic promoters. The first part of this review focuses on the recent achievements reported with metal-free systems via organocatalytic (nucleophilic, cationic and bifunctional) as well as enzymatic approaches. The second part of the review concerns the heterocyclic monomers that give access to poly(alpha-hydroxy acids) such as PLAs. Two complementary approaches will be discussed: substituted 1,4-dioxane-2,5-diones and synthetic equivalents thereof. To cite this article: D. Bourissou et al., C. R. Chimie 10 (2007). (c) 2007 Academie, des sciences. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：775 / 794

页数：20

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