N-Heterocyclic Carbene (NHC)-Catalyzed Intermolecular Hydroacylation of Cyclopropenes

被引：122

作者：

Bugaut, Xavier ^{[1
]}

Liu, Fan ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 21期

关键词：

STETTER REACTION; NHC; DESYMMETRIZATION; DERIVATIVES; ALDEHYDES; ADDITIONS; RINGS;

D O I：

10.1021/ja202594g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the first intermolecular NHC-catalyzed hydroacylation of electron-neutral olefins. Treatment of aromatic aldehydes with cyclopropenes under mild conditions affords valuable acylcyclopropanes in moderate to high yields with an excellent level of diastereocontrol. Preliminary mechanistic studies suggest that product formation occurs via a concerted syn hydroacylation pathway.

引用

页码：8130 / 8133

页数：4

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