Chromosomal localization of three human genes encoding bone morphogenetic protein receptors

被引：24

作者：

Åström, AK

Jin, D

Imamura, T

Röijer, E

Rosenzweig, B

Miyazono, K

ten Dijke, P

Stenman, G ^{[1
]}

机构：

[1] Gothenburg Univ, Sahlgrens Hosp, Dept Pathol, Canc Genet Lab, S-41345 Gothenburg, Sweden

[2] Biomed Ctr, Ludwig Inst Canc Res, S-75124 Uppsala, Sweden

[3] Japanese Fdn Canc Res, Inst Canc, Dept Biochem, Toshima Ku, Tokyo 170, Japan

[4] Creat Biomol Inc, Hopkinton, MA 01748 USA

[5] Amgen Inc, Boulder, CO 80301 USA

来源：

MAMMALIAN GENOME | 1999年 / 10卷 / 03期

关键词：

D O I：

10.1007/s003359900990

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone morphogenetic proteins (BMPs) are members of the TGF-beta superfamily that play a pivotal role in bone formation during embryogenesis and fracture repair. BMP signaling occurs via hetero-oligomeric serine/threonine kinase complexes of BMP type I (BMPR-IA or BMPR-IB) and type II receptors (BMPR-II). BMPR-IA and IB are closely related receptors, with sequence differences conserved between different species, suggesting that they serve distinct functions. Here we report the cDNA cloning of human BMPR1B and the chromosomal localization of all three BMPR genes. Using somatic cell hybrid and FISH analyses, the BMPR1A, BMPR1B, and BMPR2 genes were assigned to 10q23, 4q22-24, and 2q33-34, respectively. A processed BMPR1A pseudogene was mapped to 6q23.

引用

页码：299 / 302

页数：4

共 24 条

[21] FINE MAPPING OF THE HUMAN BONE MORPHOGENETIC PROTEIN-4 GENE (BMP4) TO CHROMOSOME 14Q22-Q23 BY IN-SITU HYBRIDIZATION [J].